The most dramatic and rapidly occurring changes in the women around the age 50 is menopause. The level of cycling estradiol (E2) production during the reproductive years drops dramatically. Not long ago, the prevailing view was that menopause resulted from an exhaustion of ovarian follicles. An alternative perspective is that age-related changes in the central [...]

The two clinically most important changes in endocrine activity during aging involve the pancreas and the thyroid. Approximately 40% individuals 65 to 74 years old and 50% individuals order than 80 years have impaired glucose tolerance or diabetes mellitus, and are risk developing marcovascular, complications at an accelerated rate. Pancreatic insulin receptor, and post-receptor changes [...]

With age comes a diminished capacity for cellular protein synthesis, a decline in immune function, an increase in fat mass, a loss of muscle mass and strength and a decrease in bone mineral density. Age-related disability is synonymous weakness, impaired mobility, balance, and poor endurance. In the very elderly it is called physical frailty and [...]

NEW ORLEANS — Testosterone replacement therapy may be of cardiovascular benefit in a sizable proportion of men with coronary heart disease Dr. Chris J. Malkin said at the annual meeting of the American College of Cardiology. Testosterone replacement reduced elevated levels of inflammatory cyto-kines in a group of men with CHD and symptomatic androgen deficiency [...]

SAN FRANCISCO — Adding testosterone replacement therapy to treatment with sildenafil provided short-term improvements in erectile dysfunction in a study of 75 hypogonadal men who did not respond to sildenafil alone, Ridwan Shabsigh, M.D., said at the annual meeting of the American Urological Association. When 100 mg/day of the phosphodiesterase type 5 (PDE5) inhibitor sildenafil [...]