SAN DIEGO, CA – Oregon Health & Science University researchers will unveil research results that help explain why middle-aged women develop central body fat. The announcement will take place during the 2005 Society for Endocrinology annual meeting today in San Diego. The OHSU research team has also conducted initial testing of estrogen replacement therapy as [...]

Question: Does a reduction in visceral fat reverse the deregulation of carbohydrate metabolism and the risk of age-associated disease? The link between obesity and disease of aging has been confirmed in studies using calorically limited to approximately 65% of their ad labium caloric intake, the mass of tat tissue is markedly decreased and the animals [...]

The most dramatic and rapidly occurring changes in the women around the age 50 is menopause. The level of cycling estradiol (E2) production during the reproductive years drops dramatically. Not long ago, the prevailing view was that menopause resulted from an exhaustion of ovarian follicles. An alternative perspective is that age-related changes in the central [...]

With age comes a diminished capacity for cellular protein synthesis, a decline in immune function, an increase in fat mass, a loss of muscle mass and strength and a decrease in bone mineral density. Age-related disability is synonymous weakness, impaired mobility, balance, and poor endurance. In the very elderly it is called physical frailty and [...]

The two clinically most important changes in endocrine activity during aging involve the pancreas and the thyroid. Approximately 40% individuals 65 to 74 years old and 50% individuals order than 80 years have impaired glucose tolerance or diabetes mellitus, and are risk developing marcovascular, complications at an accelerated rate. Pancreatic insulin receptor, and post-receptor changes [...]